Unlockable Content after you beat the game:
- Alternate costume
- Infinity ammo
- Mercenaries
- New Game +
- Play as Sheva
Unlockable Content after you beat the game on Amateur Difficulty level:
- Classic Horror Filter
Unlockable Content after you beat the game on Normal Difficulty level:
- Retro Filter
Unlockable Content after you beat the game on Veteran Difficulty level:
- Noise Filter
- Professional Mode
How to get infinite item:
Take all the items at the beginning and then quit the game. Return to the game again by selecting ‘continue’ option, and you will start with the items you took before, but those items will be available again at their original places. Repeat it as many as you want to. This trick can be done from chapter 2. For example, if you’re on chapter 2-1, and you quit the game after you took all the items, you will continue from the beginning of chapter 2-1 with items which are available again at their original places.
Unlockable costumes for campaign:
You can get alternate costumes for characters for campaign by doing these methods:
Clubbin’ Sheva:
- Beat the game
S.T.A.R.S Chris
- Shoot 25 BSAA emblems
Safari Chris
- Beat the game
Tribal Sheva
- Shoot 30 BSAA emblems
Unlockable Guns
| Name | Type | How to Unlock |
| Gatling Gun | Chris only | Fully upgrade the VZ61 then buy the Gatling gun from the shop |
| Hydra | Chris & Sheva | Fully upgrade the Ithaca M37 then buy the Hydra from the shop |
| Longbow | Sheva only | Fully upgrade S75 then buy the longbow from the shop |
| M93R | Chris & Sheva | Fully upgrade the M92F then buy the M93R from the shop |
| S&W M500 Magnum (HandCannon) | Chris & Sheva | Fully upgrade the S&W M29 Magnum then buy the S&W M500 from the shop |
Unlockable Home Items
After you completed these following tasks, you can get these Resident Evil 5 items in Home (PS3 exclusive)
| Name | How to Unlock |
| Chris Redfield Ornament | Sign in to Home and you will automatically get it |
| Jill Valentine Ornament | Beat the game on veteran difficulty level |
| Sheva Alomar Ornament | Beat the game on normal difficulty level |
| Treasure Chest Ornament | Collect all treasures in the game |
| Wesker Ornament | Beat the game on professional |
Unlockable Characters in Versus Mode
After you completed these following tasks, you can get these characters for the DLC Versus Mode
| Name | Costume | How to Unlock |
| Chris | S.T.A.R.S | Unlock him through the Bonus Features menu at the cost of 13,000 Exchange Points |
| Chris | Safari | Unlock him through the Bonus Features menu at the cost of 8,000 Exchange Points |
| Jill | Battle Suit | Unlock her through the Bonus Features menu at the cost of 5,000 Exchange Points |
| Jill | BSAA | Unlock her through the Bonus Features menu at the cost of 5,000 Exchange Points |
| Sheva | Clubbin’ | Unlock her through the Bonus Features menu at the cost of 6,000 Exchange Points |
| Sheva | Tribal | Unlock her through the Bonus Features menu at the cost of 15,000 Exchange Points |
| Wesker | Midnight | Unlock him through the Bonus Features menu at the cost of 30,000 Exchange Points |
| Wesker | S.T.A.R.S | Unlock him through the Bonus Features menu at the cost of 50,000 Exchange Points |
Unlockable Characters in Mercenaries Mode
After you completed these following tasks, you can get these characters for the Mercenaries Mode.
| Name | Costume | How to Unlock |
| Chris | S.T.A.R.S | Get an A rank on Experimental Facility |
| Chris | Safari | Get an A rank on Experimental Village |
| Jill | Battle Suit | Get an A rank on Experimental Ship Deck |
| Jill | BSAA | Get an A rank on Experimental Public Assembly |
| Sheva | Clubbin’ | Get an A rank on Experimental Ancient Ruins |
| Sheva | Tribal | Get an A rank on Experimental Missile Area |
| Wesker | Midnight | Get an A rank on Experimental Mines |
| Wesker | S.T.A.R.S | Get an A rank on Experimental Prison |
Article from Gamersyndrome.com
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