So I have scanned several top Comic Book Game lists and came up with these as the best ones using my own biase.
5. Mortal Kombat vs. DC Universe (Xbox 360, PS3)
This is the game that answered plenty of fanboy questions. Not only did this add to the fighting genera, it did so with some of the most iconic characters in comic book history.
4.Marvel VS Capcom 2 (Xbox Live Arcade)
This is similar to MK VS DC Universe except for the fact that it feels more like a classic arcade fighting game and cost only about $15. Also it includes both Marvel and Street Fighter characters which answers plenty other fanboy questions.
3.Spider Man 2 (PS2, GameCube, PC)
Basically this was one of the earliest free roaming open world games other than GTA which was acceptable for kids and had a lot of depth to its gameplay.
2. Batman Arkham Asylum (Xbox 360, PS3)
Is an open world button mashing/stealth combat game with an epic storyline. There is plenty to do in this rich game and its good price tag makes this game a must have. I might be able to legitimately say even Marvel fanboys will enjoy this game.
1.Marvel Ultimate Alliance (PS2, Xbox, PS3, Xbox 360)
This RPG brings the Marvel Universe Together with dozens of your favourite heros to play as and villains to defeat this is a must have game for comic book connoisseurs. On top of that is tons of extras including alternate costumes. This game does not shy from details.
Article from Gamersyndrome.com